Key result
Heterologous coexpression of β2 induced larger calcium currents and marked stimulation of rapid gating compared to β3 isoforms, potentially explaining altered single channel behavior in heart failure.
Cardiac β-subunit isoforms differentially modulate calcium inward currents, and increased β3trunc expression may account for altered single channel behavior in human heart failure.
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β-subunit isoform expression in human myocardium leaves open targeted Ca channel modulation in ischemic HF; functional validation required before any clinical consideration.
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Hullin et al. (2003) studied Heart failure (ischemic cardiomyopathy). β2 and β3 subunit isoforms was evaluated on Calcium inward currents and single channel characteristics. Heterologous coexpression of β2 induced larger calcium currents and marked stimulation of rapid gating compared to β3 isoforms, potentially explaining altered single channel behavior in heart failure.
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