Key result
A meta-analysis of five randomized controlled trials found no evidence for the efficacy of nalmefene compared with placebo in treating alcohol dependence.
Why the study?
Does nalmefene improve efficacy in treating alcohol dependence in adults?
Meta-Analysis (n=2,567)
Does nalmefene improve efficacy in treating alcohol dependence in adults?
A meta-analysis of 5 trials found no evidence supporting the efficacy of nalmefene for treating alcohol dependence, questioning regulatory approvals for this indication.
Questions nalmefene use for alcohol dependence; challenges regulatory approvals.
Current evidence from randomised controlled trials does not support the use of the opioid antagonist nalmefene for treating alcohol dependence, shows a systematic review that the authors said questioned decisions by some regulatory authorities to approve the drug for this indication. The review, published in PLoS Medicine , analysed all available randomised controlled trials evaluating nalmefene to treat alcohol dependence in adults.1 The researchers included five trials that met their inclusion criteria to compare the opioid antagonist with placebo, in 2567 adults with alcohol dependence. Their results …
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Susan Mayor (2015) conducted a meta-analysis in Alcohol dependence (n=2,567). Nalmefene vs. Placebo was evaluated. A meta-analysis of five randomized controlled trials found no evidence for the efficacy of nalmefene compared with placebo in treating alcohol dependence.
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