Identification of a novel deeply quiescent neural stem cell population in the subventricular zone: a potential source for brain repair

Canonically, adult neurogenesis occurs in two regions of the mammalian brain, the ventricular-subventricular zone (V-SVZ) and the subgranular zone, and modulates associated brain circuitry 1 . The V-SVZ lining the walls of the lateral ventricles harbors the largest neurogenic niche in mammals 2 . In rodents, quiescent neural stem cells (qNSCs) in the V-SVZ give rise to transit-amplifying cells, which differentiate into neuroblasts and further migrate to the olfactory bulb to produce interneurons 3 . Interestingly, in adult humans, the neurogenic niche of the V-SVZ can produce new neurons that integrate into the striatum 4 , 5 . The ability to modulate the generation and integration of new neurons in the adult brain holds the promise of treating several neurodegenerative diseases. Therefore, it has been the focus of intensive research over the last few decades 6 .