Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease

Thomas H. Oosterhof; Eleanor Mitchell; Alberto Ascherio; Stella Aslibekyan; Viktoria Azoidou; Kara Beasley; Yoav Ben-Shlomo; Eline Bunnik; Camille Carroll; Lana Chahine; Daniel Corcos; Jules M. Janssen Daalen; Karin D. van Dijk; Bauke W. Dijkstra; Lisanne Dommershuijsen; Ray Dorsey; Luc J. W. Evers; Rick C. Helmich; Martin Johansson; Lucy Norcliffe-Kaufmann; Jessi Keavney; Christine Klein; Matthew J. Kmiecik; Thomas Kustermann; Eric A. Macklin; Kenneth Marek; Sanne K. Meles; Sebastiaan Overeem; Carl M. Philpott; Angelique Pijpers; Ronald B. Postuma; Helen M. Rowbotham; Sabine Schootemeijer; Michael A. Schwarzschild; Tanya Simuni; Michael Sommerauer; Ambra Stefani; Kenan Steidel; Marcel Verbeek; Rick van der Vliet; Nienke M. de Vries; Bart van de Warrenburg; Richard K. Wyse; Bastiaan R. Bloem; Ruth B. Schneider; Alastair J. Noyce; Sirwan K. L. Darweesh

doi:10.1038/s41531-026-01463-z

July 14, 2026npj Parkinson s DiseaseOpen Access

Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease

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Key Points

This research aims to evaluate the efficacy and feasibility of a remotely delivered exercise intervention for preventing Parkinson's disease.
Conducted three randomized trials across different populations: iRBD, hyposmia, and LRRK2/GBA1 mutation carriers.
Each trial involves a comparative analysis of a gamified exercise intervention versus an active control.
Participants are followed for 18–36 months to assess outcomes.
The trials aim to provide evidence of the intervention's feasibility over time.
Preliminary efficacy measures will be evaluated for behavior change in targeted populations.
Insights will guide future large-scale studies in Parkinson's disease prevention.

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Implication

Randomized trial examines exercise intervention to prevent Parkinson’s disease in prodromal subgroups, indicating an innovative approach to prevention.

Abstract

We describe the design of the first non-pharmacological Parkinson’s disease prevention trials worldwide: the randomised ‘Slow-SPEED’ trials. Three trials examine the feasibility and preliminary efficacy of a gamified, remotely administered exercise intervention vs. active control over 18–36 months in complementary prodromal subgroups: iRBD( n = 110; Netherlands), hyposmia( n = 110; United Kingdom) or LRRK2/GBA1 mutation carriers( n = 600; United States). These trials will provide unique insights for large-scale Parkinson’s prevention studies. Protocols are registered at ClinicalTrials.gov(NCT06193252[1-5-2024];NCT06600438[9-19-2024];NCT06993142[5-28-2025]).

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Oosterhof et al. (2026) studied this question.

synapsesocial.com/papers/6a5874972b46c88ba9ad09f4 https://doi.org/10.1038/s41531-026-01463-z

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Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease

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Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease

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