What question did this study set out to answer?

This research aims to evaluate the efficacy and feasibility of a remotely delivered exercise intervention for preventing Parkinson's disease.

July 16, 2026Open Access

Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease

TOThomas H. OosterhofRadboud University Nijmegen EMEleanor MitchellQueen Mary University of London AAAlberto AscherioHarvard University

Key Points

This research aims to evaluate the efficacy and feasibility of a remotely delivered exercise intervention for preventing Parkinson's disease.
Conducted three randomized trials across different populations: iRBD, hyposmia, and LRRK2/GBA1 mutation carriers.
Each trial involves a comparative analysis of a gamified exercise intervention versus an active control.
Participants are followed for 18–36 months to assess outcomes.
The trials aim to provide evidence of the intervention's feasibility over time.
Preliminary efficacy measures will be evaluated for behavior change in targeted populations.
Insights will guide future large-scale studies in Parkinson's disease prevention.

Abstract

Abstract We describe the design of the first non-pharmacological Parkinson’s disease prevention trials worldwide: the randomised ‘Slow-SPEED’ trials. Three trials examine the feasibility and preliminary efficacy of a gamified, remotely administered exercise intervention vs. active control over 18–36 months in complementary prodromal subgroups: iRBD( n = 110; Netherlands), hyposmia( n = 110; United Kingdom) or LRRK2/GBA1 mutation carriers( n = 600; United States). These trials will provide unique insights for large-scale Parkinson’s prevention studies. Protocols are registered at ClinicalTrials.gov(NCT061932521-5-2024;NCT066004389-19-2024;NCT069931425-28-2025).

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