An Intelligent Wound Dressing Platform Based on Natural pH ‐Sensors From Syzygium cumini

This study reports the development and characterization of bioactive films based on sodium alginate and hyaluronate, incorporating a lyophilized Syzygium cumini (jambolan) extract. The primary application of these materials is the monitoring and treatment of bacterial infections in wounds. S. cumini fruit extract was selected due to its inherent pH‐responsive colorimetric properties and antibacterial activity, enabling its use as the active component in a biosensor film. Films were prepared with extract concentrations of 5%, 10%, and 20%. In vitro and ex vivo analyses confirmed that films with 5% and 10% extract exhibited a color change from burgundy to green upon contact with surfaces contaminated by Staphylococcus aureus and Pseudomonas aeruginosa . This chromatic transition indicates an increase in pH, a key biomarker of wound infection. In addition to visual detection, the films demonstrated significant antibacterial efficacy, as evidenced by the formation of inhibition zones. Mechanical analyses revealed that incorporating the extract produced films with mechano‐compatibility suitable for skin contact, an essential property for wound‐dressing applications. These results demonstrate the potential of these sustainable films to function as intelligent wound dressings that can both treat and visually signal bacterial infections.