Why the study?
High-sensitivity cardiac troponin assays detect low concentrations in asymptomatic individuals, prompting expert review of hs-cTnI for cardiovascular risk stratification and its additive value in the general population.
Does high-sensitivity cardiac troponin I (hs-cTnI) testing improve cardiovascular risk stratification for predicting cardiovascular events and mortality in apparently healthy individuals?
Does high-sensitivity cardiac troponin I (hs-cTnI) testing improve cardiovascular risk stratification for predicting cardiovascular events and mortality in apparently healthy individuals?
This expert consensus document supports the incorporation of hs-cTnI testing as an additional tool for cardiovascular risk stratification in apparently healthy individuals.
Answers are grounded in this paper and cite their sources.
hs-cTn may support CV risk stratification in asymptomatic adults; leaves open whether routine use improves outcomes.
Troponin I and T as cardiac-specific biomarkers are highly useful tools not only in the diagnosis of acute coronary syndromes but also as independent predictors of several other clinical conditions. High-sensitivity cardiac troponin (hs-cTn) assays allow the detection of considerably low concentrations of cardiac troponin in apparently healthy and asymptomatic individuals, being a candidate tool for cardiovascular risk stratification in the general population. A group of Greek experts summarized the bulk of evidence regarding the use of hs-cTnI as a predictor of cardiovascular events and mortality in apparently healthy individuals and its additive value on top of existing risk stratification methods. This document could serve as a guide for the incorporation of hs-cTnI as an additional risk stratification tool in cardiovascular prevention strategies in apparently healthy individuals.
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Farmakis et al. (2023) conducted a review in Apparently healthy individuals. High-sensitivity cardiac troponin I (hs-cTnI) was evaluated on Cardiovascular events and mortality. High-sensitivity cardiac troponin I (hs-cTnI) serves as a predictor of cardiovascular events and mortality in apparently healthy individuals, offering additive value to existing risk stratification.
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