Atractylodis Macrocephalae Rhizoma ameliorates diarrhea induced by cold drinks and a high-fat diet by remodeling gut microecology and restoring barrier function
Randomized trial demonstrates AMR's effects on diarrhea in mice, indicating a role in gut health restoration.
Key Points
This study aims to investigate the effects and mechanisms of Atractylodis Macrocephalae Rhizoma on diarrhea induced by cold drinks and a high-fat diet.
A diarrhea model was established in ICR mice exposed to a cold drinks and high-fat diet for four weeks.
AMR was administered in low/high doses via oral gavage, and bowel movements were assessed.
Gut microbiota profiling was conducted using 16S rDNA sequencing and systemic inflammation was evaluated through pro-inflammatory cytokines.
AMR significantly reduced diarrhea symptoms in mice, indicating efficacy against CDHFD-induced diarrhea.
AMR enhanced the gut microecology by increasing beneficial bacteria like Lachnospiraceae_NK4A136.
The treatment restored intestinal barrier integrity, reducing systemic translocation of LPS and inhibiting the NF-κB signaling pathway, leading to decreased inflammation.