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Analyzes pharmacokinetic/pharmacodynamic indices, suggesting improved modeling practices.
PKPDindex() is a free and open-source R package for analysing pharmacokinetic/pharmacodynamic (PK/PD) indices, including AUC/MIC, Cmax/MIC, and T>MIC. Development was motivated by previously identified inconsistencies in PK/PD index modelling and reporting practices. The package fits eight variations of the Emax model to data and compares model performance using the Akaike information criterion (AIC) and R2 values. As input, the package requires a dataset containing PK/PD indices and a response variable. As output, it generates tables summarising all fitted models, identifies the best-fitting model for each index, and produces customisable plots of model fits with parameter estimates. PKPDindex() is freely available on CRAN (https://CRAN.R-project.org/package=PKPDindex).
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Alabdulkarim et al. (2026) studied this question.
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