Key result
Administration of Carboplatin and Etoposide in a patient with small cell lung carcinoma without a history of heart disease was followed by the development of refractory vasospastic angina.
Case Report (n=1)
Carboplatin and Etoposide chemotherapy may induce vasospastic angina even in patients without a history of heart disease, which can be refractory to standard therapy.
May induce refractory vasospastic angina post-carboplatin/etoposide even without prior heart disease; hypothesis-generating and leaves open causality.
We report here a case of vasospastic angina following the administration of Carboplatin (CBDCA) and Etoposide (VP-16) in a patient with small cell lung carcinoma. Although these drugs are commonly used to treat small cell lung carcinoma, there has been no previous report of vasospastic angina in a patient without a history of heart disease. Therefore, we should be aware of the possibility that vasospastic angina may develop even in a patient without any history of heart disease. While calcium antagonist and isosorbide dinitrate are generally helpful for preventing vasospastic angina, these drugs could not completely suppress vasospastic angina in this case.
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Yano et al. (1996) conducted a case report in Small cell lung carcinoma (n=1). Carboplatin and Etoposide was evaluated on Vasospastic angina. Administration of Carboplatin and Etoposide in a patient with small cell lung carcinoma without a history of heart disease was followed by the development of refractory vasospastic angina.
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