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July 1, 1975Proceedings of the National Academy of Sciences724 citationsOpen Access

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An octamer of histones in chromatin and free in solution.

JTJean ThomasBeni-Suef University RKRoger D. KornbergCalifornia Institute of Technology

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Resumen

Crosslinking with dimethyl suberimidate reveals a chain of histone octamers in chromatin. The octamer can be isolated free in solution at high ionic strength and pH. The identification of dimers formed by crosslinking reveals two or more contacts of each histone with others within the octamer. The molecular weight (110,000) and pattern of dissociation of the octamer are compatible with the composition (F2A1)2(F3)2(F2A2)2(F2B)2.

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Cite This Study

Thomas et al. (Tue,) studied this question.

synapsesocial.com/papers/6a5ac71a3c250e58fd489c83 https://doi.org/https://doi.org/10.1073/pnas.72.7.2626

An octamer of histones in chromatin and free in solution. | Synapse