Key result
Numerical simulations demonstrated that the perfusing bath causes an initial slowing of the action potential foot during longitudinal propagation (tau=483 micros).
Population
Numerical simulations of cardiac tissue based on the bidomain model
Design
Preclinical
Authors
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Attributes slowing to perfusing bath, not capillaries; challenges prior interpretation and leaves open in vivo relevance.
The perfusing bath plays a critical role in determining the time course of the cardiac action potential foot and must be accounted for in electrophysiological measurements.
Bradley J. Roth (2000) studied Cardiac action potential propagation. Perfusing bath was evaluated on Time course of the action potential foot (tau). Numerical simulations demonstrated that the perfusing bath causes an initial slowing of the action potential foot during longitudinal propagation (tau=483 micros).