Updated Asian consensus guidelines for the diagnosis and management of gastrointestinal stromal tumor (2025)

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor arising from the gastrointestinal tract. Accurate pathological diagnosis and appropriate treatment for this malignancy require a multidisciplinary approach. In consideration of the differences in clinical practice between Asian and Western countries, the Asian Consensus Guidelines for the Diagnosis and Management of GISTs were published in 2016 by multidisciplinary experts in Asian countries (Japan, Korea, China, and Taiwan). Given the accumulation of new evidence since the previous publication, a multidisciplinary expert panel consisting of pathologists, surgical oncologists, and medical oncologists revised the Asian consensus guidelines. This narrative review provides updated consensus recommendations reflecting available evidence, expert opinion, and current clinical practice for the diagnosis and management of GIST in Asian countries.