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July 18, 2026Human GeneticsOpen Access

Identification of a novel isoform of Slc26a4 by single-cell RNA-sequencing of pendrin-expressing cells in the cochlea

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Authors

JKJin-Young KohCACorentin AffortitKHKazuaki Homma

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Overview

Randomized trial identifies a new Slc26a4 isoform in cochlear cells, suggesting implications for hearing loss.

Key Points

  • This research aims to identify a novel isoform of the Slc26a4 gene and understand its implications for hearing loss.
  • Utilized short- and long-read single-cell RNA sequencing (scRNA-seq) of pendrin-expressing cells in murine cochlea.
  • Analyzed expression of the short Slc26a4 isoform in inner ear and kidney.
  • Investigated genotype-phenotype associations for SLC26A4-related hearing loss.
  • Detected a novel short isoform of Slc26a4 in murine cochlea.
  • Characterized expression in both inner ear and kidney.
  • Provided insights into molecular profiling of pendrin and splicing events related to SLC26A4-related hearing loss.

Cite This Study

Koh et al. (2026) studied this question.

synapsesocial.com/papers/6a5b18b318557b26c203a7d4https://doi.org/10.1007/s00439-026-02858-x
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