The effect of using a large language model to respond to patient messages

The relentless increase in administrative responsibilities, amplified by electronic health record (EHR) systems, has diverted clinician attention from direct patient care, fuelling burnout.1 In response, large language models (LLMs) are being adopted to streamline clinical and administrative tasks. Notably, Epic is currently leveraging OpenAI's ChatGPT models, including GPT-4, for electronic messaging via online portals.2 The volume of patient portal messaging has escalated in the past 5–10 years,3 and general-purpose LLMs are being deployed to manage this burden.