Patients with supraventricular tachycardia had significantly higher plasma levels of GPER, Tau, and 8-iso-PGF2α compared to healthy controls (P<.001 for all).
Observational (n=81)
Do plasma levels of GPER, 8-iso-PGF2α, and Tau protein differ between patients with supraventricular tachycardia and healthy controls?
GPER, 8-iso-PGF2α, and Tau protein are significantly elevated in patients with SVT and show strong diagnostic accuracy, suggesting a role for GPER-mediated signaling, oxidative stress, and neurodegeneration in SVT pathophysiology.
Effect estimate: Tau AUC 0.986, GPER AUC 0.981
p-value: p=<.001
Supraventricular tachycardia (SVT) is a common arrhythmic disorder characterized by abnormal electrical impulses arising from supraventricular tissues, most commonly the atria or atrioventricular node. This study aimed to investigate the association between G protein-coupled estrogen receptor (GPER) levels and biomarkers of oxidative stress and neurodegeneration in the pathophysiology of SVT. This study included 51 patients diagnosed with SVT and 30 healthy controls. Plasma levels of the oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α), the neurodegeneration-associated protein Tau, and GPER were measured using ELISA kits. Correlations between GPER and the studied biomarkers were analyzed, and the diagnostic performance of each biomarker was evaluated using ROC analysis. Pro-BNP levels were higher in patients with SVT compared to the control group ( P = .05). GPER, Tau, and 8-iso-PGF 2 α levels were significantly higher in the SVT group compared to the control group ( P < .001 for all 3 biomarkers). ROC analysis demonstrated that 8-iso-PGF 2 α had the highest diagnostic accuracy, while Tau (AUC = 0.986) and GPER (AUC = 0.981) also showed strong discriminative performance. GPER, a well-established marker of estrogen-mediated cellular signaling, emerges as a significant biomarker in patients with SVT. These findings suggest that GPER-mediated signaling pathways may be associated with systemic oxidative damage and neuronal effects in the pathophysiology of SVT.
Öztürk et al. (Fri,) conducted a observational in Supraventricular tachycardia (SVT) (n=81). Supraventricular tachycardia (SVT) vs. Healthy controls was evaluated on Plasma levels of GPER, Tau, and 8-iso-PGF2α (Tau AUC 0.986, GPER AUC 0.981, p=<.001). Patients with supraventricular tachycardia had significantly higher plasma levels of GPER, Tau, and 8-iso-PGF2α compared to healthy controls (P<.001 for all).