Key result
Diabetes linked to ~18% higher LV mass index in hypertensive hemodialysis patients.
Why the study?
Hypertension is an important predictor of left ventricular remodeling in hemodialysis patients, but diabetic patients could have an adverse myocardial phenotype.
Does diabetic status worsen left ventricular hypertrophy patterns in hypertensive patients on maintenance hemodialysis?
Cross-Sectional (n=94)
Does diabetic status worsen left ventricular hypertrophy patterns in hypertensive patients on maintenance hemodialysis?
Diabetic hypertensive patients on hemodialysis exhibit more severe left ventricular hypertrophy and concentric remodeling compared to non-diabetics, indicating a higher risk for adverse cardiovascular events.
May indicate higher CV risk warranting closer LVH monitoring in diabetic hemodialysis patients; cross-sectional data leaves open causality and needs prospective confirmation.
Background: Cardiovascular disease continues to constitute a major source of morbidity and mortality among patients with end-stage renal disease undergoing maintenance hemodialysis, with left ventricular hypertrophy being one of its structural predictors. Hypertension has been established as the important predictor of left ventricular remodeling in these patients, although diabetic patients could have an adverse myocardial phenotype. Objective: To compare the echocardiographic variables and left ventricular geometric patterns of diabetic and non-diabetic hypertensive patients undergoing maintenance hemodialysis in Peshawar, Pakistan. Methodology: This cross-sectional comparative study was conducted on 94 patients with hypertension who were on maintenance hemodialysis for at least three months, with each of the two groups having equal number of patients. Patients in each group were subjected to transthoracic echocardiography 12 to 24 hours after a mid-week dialysis session. Independent-samples t-test and Chi-square analyses were employed to compare left ventricular mass index, relative wall thickness, interventricular septum thickness, posterior wall thickness and left ventricular geometric patterns of patients belonging to the two groups. Results: Diabetic hypertensive patients had a higher left ventricular mass index than non-diabetic hypertensive patients (148.6 ± 22.4 vs 126.3 ± 18.5 g/m²; p<0.001) as well as relative wall thickness (0.48 ± 0.06 vs 0.42 ± 0.05; p<0.001). Concentric hypertrophy was observed in greater numbers of diabetic hypertensive patients than non-diabetic hypertensive patients (57.4% vs 17.0%), and eccentric hypertrophy was more prevalent in non-diabetic patients (44.7% vs 27.7%). There were significant differences in left ventricular geometry by diabetic status (χ²=13.064; p=0.004). Conclusion: Diabetic status was associated with higher left ventricular mass index, greater relative wall thickness and concentric hypertrophy in hypertensive patients under maintenance hemodialysis. Longitudinal studies should be done in future to determine the causal relationships involved
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Latif et al. (2026) conducted a cross-sectional in Hypertension on maintenance hemodialysis (n=94). Diabetic status vs. Non-diabetic status was evaluated on Left ventricular mass index (p=<0.001). Diabetic status was associated with a significantly higher left ventricular mass index (148.6 vs 126.3 g/m², p<0.001) and greater relative wall thickness in hypertensive patients on maintenance hemodialysis.
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