Key result
A case of apixaban auto-intoxication was presented to describe its toxicokinetics and effects on coagulation tests.
Case Report (n=1)
This case report provides data on the toxicokinetics and coagulation test results following an apixaban overdose.
Apixaban auto-intoxication case describes toxicokinetics and coagulation effects; leaves open questions on clinical management in overdose.
Apixaban is a direct oral anticoagulant (DOAC) that acts on the coagulation cascade by direct factor Xa inhibition. It is currently approved for the prevention and treatment of venous thromboembolism and for the prevention of stroke and systemic embolism in atrial fibrillation patients.[1] Two case reports have described an apixaban overdose thus far,[2] [3] and little is known about apixaban toxicokinetics. We present an apixaban auto-intoxication with corresponding toxicokinetics and coagulation tests.
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Mast et al. (2017) conducted a case report in Apixaban auto-intoxication (n=1). Apixaban auto-intoxication was evaluated on Toxicokinetics and coagulation tests. A case of apixaban auto-intoxication was presented to describe its toxicokinetics and effects on coagulation tests.
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