Bimetallic Reagents of Silicon: One‐Pot Synthesis of 2,3,5‐Trisubstituted Tetrahydrofurans by a Double Sakurai–Hosomi Reaction

Good yields and high stereoselectivities are found in the cyclization of 1-silylmethyl allylic silanes with aldehydes. The silanes act as bimetallic coupling reagents and effect cyclization to yield a variety of 2,3,5-trisubstituted tetrahydrofurans in a one-pot procedure. A three-component cyclization with only one product can also be achieved with this methodology (see scheme).