Key result
EVL mRNA expression was significantly elevated in breast tumors compared to matched normal tissues (P=0.032) and its up-regulation positively correlated with advanced clinical stages (P=0.021).
Population
35 paired human breast cancer specimens, and NIH3T3 and MCF-7 cell lines
Comparison
EVL overexpression (in vitro) vs Matched normal tissues; control cells
Design
Preclinical
Authors
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May inform EVL biomarker research in breast cancer; leaves open clinical relevance pending validation.
Observational (n=35)
No
Absolute Event Rate: 0.115% vs 0.0586%
p-value: p=0.032
EVL expression is up-regulated in breast cancer, correlates with advanced clinical stages, and promotes cell motility in vitro, suggesting a role in invasion and metastasis.
Hu et al. (2008) conducted an observational in Breast cancer (n=35). Breast cancer (tumor tissue) vs. Matched normal breast tissue was evaluated on Relative EVL mRNA expression level (p=0.032). EVL mRNA expression was significantly elevated in breast tumors compared to matched normal tissues (P=0.032) and its up-regulation positively correlated with advanced clinical stages (P=0.021).
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