Key result
Higher LV entropy on LGE-CMR is linked to ~71% higher MACE risk in LVNC.
Why the study?
Risk stratification of major adverse cardiac events in patients with left ventricular non-compaction remains complex with an uncertain prognosis.
Does left ventricular entropy derived from cardiac magnetic resonance late gadolinium enhancement predict major adverse cardiac events in patients with left ventricular non-compaction?
Cohort (n=86)
No
Does left ventricular entropy derived from cardiac magnetic resonance late gadolinium enhancement predict major adverse cardiac events in patients with left ventricular non-compaction?
Left ventricular entropy quantified by CMR late gadolinium enhancement acts as an independent prognostic marker for major adverse cardiac events in patients with left ventricular non-compaction.
LV entropy may refine MACE risk assessment in LVNC; leaves open its incremental value and prospective validation before clinical use.
PURPOSE: Left ventricular non-compaction (LVNC) is considered rare; however, the use of cardiac magnetic resonance (CMR) has shown that its incidence is not uncommon, and its clinical presentation remains variable, with an uncertain prognosis. Risk stratification of major adverse cardiac events (MACE) in patients with LVNC remains complex. Therefore, this study aims to determine whether tissue heterogeneity from late gadolinium enhancement-derived entropy is associated with MACE in patients with LVNC. METHODS: This study was registered in the Clinical Trial Registry (CTR2200062045). Consecutive patients who underwent CMR imaging and were diagnosed with LVNC were followed up for MACE, which was defined by heart failure, arrhythmias, systemic embolism, and cardiac death. The patients were divided into MACE and non-MACE groups. The CMR parameters included left ventricular (LV) entropy, LV ejection fraction (LVEF), LV end-diastolic volume, LV end-systolic volume (LVESV), and LV mass (LVM). CONCLUSION: LGE-derived LV entropy and LVEF are independent risk indicators of MACE in patients with LVNC. The combination of the two factors was more conducive to improving the prediction of MACE.
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Ma et al. (2023) conducted a cohort in Left ventricular non-compaction (LVNC) (n=86). Higher left ventricular entropy derived from late gadolinium enhancement CMR vs. Lower left ventricular entropy was evaluated on Major adverse cardiac events (MACE) including heart failure, arrhythmias, systemic embolism, and cardiac death (HR 1.710, 95% CI 1.078-2.714, p=0.023). Higher left ventricular entropy derived from late gadolinium enhancement was associated with a 71% increased risk of major adverse cardiac events in patients with left ventricular non-compaction.
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