Key result
Plant sterols fail to reduce eryptosis markers in statin-treated hypercholesterolemic patients.
Why the study?
Statins do not prevent eryptosis, but plant sterols have shown anti-eryptotic effects ex vivo alongside cholesterol-lowering activity, which could help decrease cardiovascular disease risk.
Does a plant sterol food supplement (2 g/day) improve eryptotic parameters and cardiometabolic markers in hypercholesterolemic subjects treated with statins?
RCT (n=26)
Double-blind, placebo-controlled
Randomly divided into 2 groups (Random Allocation Software 2.0)
No
Does a plant sterol food supplement (2 g/day) improve eryptotic parameters and cardiometabolic markers in hypercholesterolemic subjects treated with statins?
A 6-week plant sterol food supplement did not alter eryptosis or further lower LDL-c in statin-treated hypercholesterolemic patients, but it decreased erythrocyte endothelial adhesion and increased Apo A1 levels, suggesting potential auxiliary vascular benefits.
Answers are grounded in this paper and cite their sources.
No support for plant sterols targeting eryptosis in statin users; extends evidence on reduced erythrocyte-endothelial adhesion.
Eryptotic erythrocytes are prone to adhere to the vascular endothelium, provoking atherosclerosis. As statins do not prevent eryptosis compounds with anti-eryptotic effects could help treated hypercholesterolemic subjects in decreasing cardiovascular disease risk. Plant sterols (PSs) have shown this anti-eryptotic effect ex vivo, along with their cholesterol-lowering activity. A parallel double-blind placebo-controlled randomized trial was conducted using a PS-food supplement (2 g of PS/day) (case, n = 13) or a placebo supplement (control, n = 13) in statin-treated hypercholesterolemic subjects. Blood samples were extracted before (T0) and after (T1) a 6-week treatment, and erythrocytes were isolated for biochemical determination, phosphatidylserine externalization (EPHS), cell size and reduced glutathione (GSH) analyses, and endothelium adhesion evaluation. A reduction in glucose (4.3%) and LDL cholesterol (9.2%) was observed only in the control group, whereas in the case group, an increase in ApoA1 (6.4%) was observed. Neither EPHS, cell size nor GSH were modified by the treatment with any of the supplements, whilst endothelium adhesion was reduced (55.1%) only in the case group. These results suggest that the PS supplement may improve some cardiovascular health parameters in the target population even though eryptosis status is not modified by this treatment.
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Miedes et al. (2024) conducted an RCT in Mild hypercholesterolemia under statin treatment (n=26). Plant sterol (PS) food supplement vs. Placebo supplement without enrichment was evaluated on Phosphatidylserine externalization (EPHS) measuring eryptosis (p=>0.05). A daily 2 g plant sterol food supplement did not modify eryptosis markers such as EPHS but reduced erythrocyte adhesion to the endothelium by 55.1% in statin-treated hypercholesterolemic subjects.
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