Key result
Vascular smooth muscle cells in various blood vessels express all three nitric oxide synthase isoforms, suggesting an endothelium-independent mechanism for modulating vascular functions.
This study provides the first evidence that vascular smooth muscle cells express all three NOS isoforms, suggesting an endothelium-independent mechanism for local NOS modulation of vascular functions.
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Challenges endothelium-centric NO model in vessels; leaves open VSMC NOS relevance to human vascular function.
Buchwalow et al. (2002) studied this question. Nitric oxide synthase (NOS) expression was evaluated on Expression of NOS isoforms in vascular smooth muscle cells. Vascular smooth muscle cells in various blood vessels express all three nitric oxide synthase isoforms, suggesting an endothelium-independent mechanism for modulating vascular functions.
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