Key result
Intravenous thrombolysis before transfer for thrombectomy was associated with improved 3-month functional outcome compared to no IVT (OR 2.17; 95% CI 1.43-3.30; p<0.01).
Why the study?
Does intravenous thrombolysis before inter-facility transfer improve functional outcomes and recanalization in patients with acute ischemic stroke and large vessel occlusion?
Cohort (n=521)
Yes
Does intravenous thrombolysis before inter-facility transfer improve functional outcomes and recanalization in patients with acute ischemic stroke and large vessel occlusion?
Administering intravenous thrombolysis before inter-facility transfer for thrombectomy in acute ischemic stroke is associated with improved recanalization and functional outcomes without increasing the risk of intracerebral hemorrhage.
OBJECTIVE: Patients with acute ischemic stroke and large vessel occlusion (LVO) often require transfer from primary stroke centers (PSCs) to thrombectomy-capable centers. This study assessed the efficacy and safety of intravenous thrombolysis (IVT) initiated before inter-hospital transfer. METHODS: Data from 2 prospective cohorts of patients with anterior circulation LVO transferred for thrombectomy from a PSC, regardless of whether thrombectomy was eventually attempted at the endovascular-capable center, were analyzed. Efficacy outcomes included good 3-month functional outcome (modified Rankin scale [mRS] = 0-2), excellent functional outcome (mRS = 0-1), and arterial recanalization during transfer. Safety outcomes included any intracerebral hemorrhage (ICH) and symptomatic ICH (sICH) at 24 hours. Propensity score with overlap weighting balanced the covariates between patients treated with IVT versus those without. RESULTS: Of 521 patients, 260 (50%) received IVT before transfer. IVT was withheld mainly due to being outside the 4.5-hour window (58%) or anticoagulant use (21%). Median age was 72 years, 55% were men, and median baseline National Institutes of Health Stroke Scale (NIHSS) was 15. After propensity score with overlap weighting, patients receiving IVT more frequently had good functional outcome (odds ratio [OR] = 2.17, 95% confidence interval [CI] = 1.43-3.30, p < 0.01), excellent functional outcome (OR = 1.99, 95% CI = 1.21-3.25, p < 0.01), and inter-facility recanalization (OR = 5.64, 95% CI = 2.92-10.89, p < 0.01) compared with patients not treated with IVT. Any ICH (OR = 1.14, 95% CI = 0.76-1.70) and sICH (OR = 0.73, 95% CI = 0.36-1.51) rates were similar between groups. INTERPRETATION: IVT before transfer was associated with improved recanalization and functional outcomes without increasing safety risks but is used in only 50% of patients. Expanding IVT criteria, including treatment beyond 4.5 hours and in anticoagulated patients, should be explored. ANN NEUROL 2025;98:871-880.
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Seners et al. (2025) conducted a cohort in Acute ischemic stroke and large vessel occlusion (LVO) (n=521). Intravenous thrombolysis (IVT) vs. No intravenous thrombolysis was evaluated on Good 3-month functional outcome (mRS 0-2) (OR 2.17, 95% CI 1.43-3.30, p=< 0.01). Intravenous thrombolysis before transfer for thrombectomy was associated with improved 3-month functional outcome compared to no IVT (OR 2.17; 95% CI 1.43-3.30; p<0.01).
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