Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia

In a recent study published in Nature , Bilgic et al. have elucidated a crucial role of Ectodysplasin A2 receptor (EDA2R) and its downstream effector, NF-κB-inducing kinase (NIK), in the pathogenesis of cancer cachexia. This discovery suggests interventional potential to ameliorate muscle loss by targeting EDA2R signaling. 1