Endothelial Endothelin Receptor A Expression Is Associated With Podocyte Injury and Oxidative Stress in Patients With Focal Segmental Glomerulosclerosis

INTRODUCTION: R) expression in patients with FSGS and its association with podocyte injury and glomerular oxidative stress. METHODS: R-positive endothelium and with nephrin loss were scored, and the 8-oxo-guanine-positive glomerular area was measured. RESULTS: = 0.037). Finally, 8-oxo-guanine positivity in glomeruli was associated with increased levels of proteinuria. CONCLUSION: R is increased in glomerular endothelial cells of patients with FSGS and associated with podocyte damage and glomerular oxidative stress. These findings support the hypothesis that ET-1 signaling in glomerular endothelial cells contributes to disease development in patients with FSGS.