Key result
Diminazene aceturate prevented the development of pulmonary hypertension in rat models and corrected the dysfunction of angiogenic progenitor cells isolated from patients with pulmonary hypertension.
Why the study?
Does diminazene aceturate prevent or reverse pulmonary hypertension in experimental models?
Does diminazene aceturate prevent or reverse pulmonary hypertension in experimental models?
Diminazene aceturate shows therapeutic potential for pulmonary hypertension by enhancing ACE2 activity and improving angiogenic progenitor cell function in experimental models.
DIZE effects in rat PH models warrant no clinical action; leaves open translation to human disease.
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Shenoy et al. (2013) studied Pulmonary hypertension. Diminazene aceturate (DIZE) was evaluated on Development and progression of pulmonary hypertension, and angiogenic progenitor cell function. Diminazene aceturate prevented the development of pulmonary hypertension in rat models and corrected the dysfunction of angiogenic progenitor cells isolated from patients with pulmonary hypertension.
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