The clinical effectiveness of preimplantation genetic diagnosis for aneuploidy in all 24 chromosomes (PGD-A): systematic review

Evelyn Lee; Peter Illingworth; L. Wilton; Georgina Chambers

doi:10.1093/humrep/deu303

November 28, 2014Human ReproductionOpen Access

The clinical effectiveness of preimplantation genetic diagnosis for aneuploidy in all 24 chromosomes (PGD-A): systematic review

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Key Points

The research aims to assess whether preimplantation genetic diagnosis for aneuploidy (PGD-A) is clinically and cost-effective during assisted reproductive technology (ART).
Conducted a systematic review of literature in multiple databases including MEDLINE and Cochrane Library.
Included 19 articles, comprising three randomized controlled trials (RCTs) and 16 observational studies.
Employed the Downs and Black scoring checklist for quality assessment and measured clinical effectiveness via pregnancy, live birth, and miscarriage rates.
Four out of five controlled studies reported improved implantation rates with PGD-A.
Six of the eight studies that included a control group observed significantly higher pregnancy rates in the PGD-A group.
Study indicated benefits in clinical pregnancy rates, particularly with single embryo transfer for young patients.

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Implication

Systematic review evaluates preimplantation genetic diagnosis for aneuploidy, suggesting uncertain clinical effectiveness in assisted reproductive technology.

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Lee et al. (2014) studied this question.

synapsesocial.com/papers/6a5bc764c79753f37d04c3e1 https://doi.org/10.1093/humrep/deu303

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The clinical effectiveness of preimplantation genetic diagnosis for aneuploidy in all 24 chromosomes (PGD-A): systematic review

Key Points

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The clinical effectiveness of preimplantation genetic diagnosis for aneuploidy in all 24 chromosomes (PGD-A): systematic review

Key Points

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