Key result
High laminar shear flow stabilizes vessels via KLF2, whereas disturbed flow increases endothelial cell turnover and inflammatory responses via NFκB, with YAP acting as a co-regulator.
This review highlights the mechanisms by which different blood flow patterns regulate endothelial cell function and atherogenesis through specific transcription factors like KLF2, NFκB, and YAP.
No takes yet. Share an insight, caveat, or question.
High laminar shear inhibits endothelial proliferation to stabilize vessels; leaves open flow-targeted interventions in atherosclerosis.
Nakajima et al. (2017) reported a review. Blood flow patterns (laminar vs disturbed flow) was evaluated. High laminar shear flow stabilizes vessels via KLF2, whereas disturbed flow increases endothelial cell turnover and inflammatory responses via NFκB, with YAP acting as a co-regulator.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: