Key result
Higher visit-to-visit fasting glucose variability in young adulthood was associated with subclinical changes in left ventricular diastolic function at midlife, including lower e' (β -0.214, P<0.01).
Why the study?
It was unclear whether greater visit-to-visit fasting glucose variability in young adulthood among a community population is associated with cardiac function alteration and remodeling at midlife.
Is higher visit-to-visit fasting glucose variability in young adulthood associated with altered cardiac structure and function at midlife?
Cohort (n=2,600)
Is higher visit-to-visit fasting glucose variability in young adulthood associated with altered cardiac structure and function at midlife?
Higher fasting glucose variability in young adulthood is associated with subclinical left ventricular diastolic dysfunction at midlife, suggesting long-term cardiac consequences of glycemic fluctuations.
Greater young-adult FG variability was associated with midlife cardiac changes; hypothesis-generating, prospective trials needed before practice implications.
Glycemic variability was found associated with left ventricular structure and function in type 2 diabetes. But it is still unclear that whether the greater visit-to-visit fasting glucose (FG) variability in young adulthood among the community population is associated with cardiac function alteration and cardiac remodeling at midlife. The community-based prospective cohort study of Coronary Artery Risk in Young Adult (CARDIA) recruited young participants at the baseline age of 18–30 years during the period of 1985–1986 (Year 0). FG was measured at Year 0, 2, 10, 15, 20, and 25. The echocardiographic evaluation of cardiac structure and function was conducted at year 25. A total of 2,600 young adults mean (SD) aged at 24.9 years (3.6) of which 57.3% were women and 46.7% were African Americans had been included in the study. After multivariable adjusted, higher SD of mean FG (SD FG ) is associated with lower early peak diastolic septal mitral annular velocity (e') (β [SE], −0.214 [0.080], P < 0.01) and higher E/e' (β [SE], 0.307 [0.094], P < 0.01), and higher coefficient of variation of the mean FG (CV FG ) is also associated with lower e' (β [SE], −0.141[0.066], P < 0.05) and higher E/e' (β [SE], 0.204 [0.078], P < 0.01). The higher average real variation of mean FG (ARV FG ) is associated with higher E/e' (β [SE], 0.178 [0.085], P < 0.05) and higher left ventricular mass index (LVMI) (β [SE], 1.240 [0.618], P < 0.05). The higher FG variability in young adulthood is associated with the subclinical change of left ventricular (LV) diastolic function at midlife.
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Xiong et al. (2021) conducted a cohort in Community population (n=2,600). Visit-to-visit fasting glucose variability vs. Lower fasting glucose variability was evaluated on Early peak diastolic septal mitral annular velocity (e') (β -0.214 (SE 0.080), p=< 0.01). Higher visit-to-visit fasting glucose variability in young adulthood was associated with subclinical changes in left ventricular diastolic function at midlife, including lower e' (β -0.214, P<0.01).
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