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In the typical two-group clinical trial with outcomes of either success or failure, investigators are interested in finding out whether an innovative treatment, T, reduces the frequency of failure relative to standard therapy, S. If pT and pS are used to represent the respective frequencies, this question can be answered by testing the null hypothesis of equal efficacy, H0: pT = pS, against the alternative hypothesis of superiority, HA: pT < pS. If the null hypothesis can be rejected in favor of the alternative hypothesis, we conclude that . . .
Ware et al. (Thu,) studied this question.