What is the clinical evidence from this study?

Study design: Other. Population: K+ channel gating. Intervention: Molecular dynamics simulations. Primary outcome: Permeation and gating mechanisms.

March 15, 2010Proceedings of the National Academy of SciencesOpen Access

Principles of conduction and hydrophobic gating in K + channels

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Key result

Molecular dynamics simulations of the Kv1.2 pore domain revealed a knock-on conduction mechanism and a novel hydrophobic gating mechanism driven by dewetting of the pore cavity.

Authors

MJMorten Ø. JensenD. E. Shaw Research DBDavid W. BorhaniGinkgo Bioworks, Inc. (United States)KLKresten Lindorff‐LarsenUniversity of Copenhagen

Discussion

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Implication

Atomic insights into K+ channel permeation extend biophysical models; hypothesis-generating for therapies pending in vivo validation.

PICO

Population

K+ channel gating

Intervention / Comparator

Molecular dynamics simulations

Primary Outcome

Permeation and gating mechanisms

Cite This Study

Jensen et al. (2010) studied K+ channel gating. Molecular dynamics simulations was evaluated on Permeation and gating mechanisms. Molecular dynamics simulations of the Kv1.2 pore domain revealed a knock-on conduction mechanism and a novel hydrophobic gating mechanism driven by dewetting of the pore cavity.

synapsesocial.com/papers/6a5bfcec68f4367e1704ea92 https://doi.org/10.1073/pnas.0911691107

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Principles of conduction and hydrophobic gating in K + channels

Discussion

Member takes

Implication

PICO

Cite This Study

Principles of conduction and hydrophobic gating in K + channels

Discussion

Member takes

Implication

PICO

Cite This Study

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