What question did this study set out to answer?

Determine the effectiveness of clomiphene citrate compared to anastrozole in raising testosterone levels in hypogonadal infertile men.

July 14, 2015The Journal of Sexual Medicine

A Randomized Prospective Double-Blind Comparison Trial of Clomiphene Citrate and Anastrozole in Raising Testosterone in Hypogonadal Infertile Men

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Determine the effectiveness of clomiphene citrate compared to anastrozole in raising testosterone levels in hypogonadal infertile men.
Randomized 26 hypogonadal infertile men to clomiphene citrate (25 mg/day) or anastrozole (1 mg/day) for 12 weeks.
Assessed total testosterone, estradiol, luteinizing hormone, follicle stimulating hormone, and sex hormone binding globulin levels at baseline, 6, and 12 weeks.
Evaluated patient-reported outcomes using standardized questionnaires at baseline, 6, and 12 weeks.
Testosterone increased significantly in both groups at 6 and 12 weeks; mean increase in CC group was 571 ng/dL vs. 408 ng/dL in AZ group.
Clomiphene citrate led to increased estradiol levels, while anastrozole resulted in decreased estradiol levels.
Significant improvement in testosterone-to-estradiol ratio observed in anastrozole group, but not in clomiphene citrate group.

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Implication

Randomized trial compares testosterone levels from clomiphene citrate and anastrozole in hypogonadal infertile men, indicating superior effects of clomiphene citrate.

Cite This Study

Helo et al. (2015) studied this question.

synapsesocial.com/papers/6a5c2165cf4f37ea7699da9f https://doi.org/10.1111/jsm.12944

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Implication

Randomized trial compares testosterone levels from clomiphene citrate and anastrozole in hypogonadal infertile men, indicating superior effects of clomiphene citrate.

A Randomized Prospective Double-Blind Comparison Trial of Clomiphene Citrate and Anastrozole in Raising Testosterone in Hypogonadal Infertile Men

Key Points

Discussion

Implication

Cite This Study

A Randomized Prospective Double-Blind Comparison Trial of Clomiphene Citrate and Anastrozole in Raising Testosterone in Hypogonadal Infertile Men

Key Points

Discussion

Implication

Cite This Study

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