Key result
Urinary NAG excretion was significantly increased in diabetic patients versus healthy controls (P<0.001) and showed 100% sensitivity and 87.5% specificity for assessing early renal damage.
Why the study?
Does urinary NAG excretion accurately detect early renal damage in diabetic patients compared to routine markers?
Case-Control (n=57)
Does urinary NAG excretion accurately detect early renal damage in diabetic patients compared to routine markers?
Urinary NAG excretion demonstrates high sensitivity and specificity as an early marker of renal damage in diabetic patients, potentially outperforming routine markers like microalbuminuria.
Answers are grounded in this paper and cite their sources.
Urinary NAG may aid earlier diabetic nephropathy detection; leaves open whether it outperforms microalbuminuria for outcomes or screening.
Diagnosis of diabetic nephropathy in the early stages is very important since there are no clinical signs or symptoms. Urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion has been recommended as a tubular dysfunction marker that elevates before other markers, such as microalbuminuria and a decrease in creatinine clearance. In this study, we compared excretion of urinary enzymes with other markers that are used routinely in diabetic nephropathy assessment. Urinary NAG, lactate dehydrogenase (LDH), alkaline phosphatase (AP) activities, urea, creatinine, and albumin, with levels of serum glucose and creatinine and whole blood glycosylated hemoglobin (HbA1c) were measured in 32 diabetes mellitus patients and 25 healthy subjects (controls). Notably, urinary NAG, AP, LDH excretion, and microalbuminuria in the diabetic patients group were significantly increased compared to those in the control groups (P<0.001, P<0.05, P<0.01, and P<0.01, respectively). Meanwhile, our results showed that the urinary NAG excretion had the highest sensitivity and specificity (100% and 87.5%, respectively) compared to other markers. We showed that measuring urinary NAG excretion could be useful for the assessment of renal failure in diabetes mellitus patients and confirmed the use of NAG as a routine screening test.
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Mohammadi‐Karakani et al. (2007) conducted a case-control in Diabetes mellitus (n=57). Urinary NAG excretion vs. Healthy controls and other markers was evaluated on Urinary NAG excretion levels and diagnostic accuracy (p=<0.001). Urinary NAG excretion was significantly increased in diabetic patients versus healthy controls (P<0.001) and showed 100% sensitivity and 87.5% specificity for assessing early renal damage.
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