Key result
Cold pressor stress induced a lower myocardial vasomotor response in collateral-dependent myocardium compared to remote myocardium (0.97 vs 1.46; P<0.05), suggesting a vasoconstrictor response.
Why the study?
Does cold pressor stress alter myocardial blood flow in collateral-dependent myocardium compared to remote myocardium?
Population
9 patients with an occluded coronary artery supplied entirely by collaterals from other angiographically…
Comparison
Cold pressor stress vs Basal state and remote myocardium
Design
Cross-sectional
Authors
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Hypothesis-generating for vasomotor dysfunction in collateral-dependent myocardium; larger studies needed before clinical relevance.
Observational (n=9)
Does cold pressor stress alter myocardial blood flow in collateral-dependent myocardium compared to remote myocardium?
Absolute Event Rate: 0.97% vs 1.46%
p-value: p=<0.05
Cold pressor stress induces a vasoconstrictor response in collateral-dependent myocardium, increasing vascular resistance without causing demonstrable ischemia.
Uren et al. (1997) conducted an observational in Occluded coronary artery supplied entirely by collaterals (n=9). Cold pressor stress vs. Remote myocardium was evaluated on Myocardial vasomotor response (cold pressor/basal flow) (p=<0.05). Cold pressor stress induced a lower myocardial vasomotor response in collateral-dependent myocardium compared to remote myocardium (0.97 vs 1.46; P<0.05), suggesting a vasoconstrictor response.
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