Key result
Sphingolipid metabolism drives atherosclerosis via inflammation and oxidative stress, highlighting novel therapeutic targets.
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This review highlights the role of sphingolipid metabolites in atherosclerosis pathogenesis, suggesting them as potential novel therapeutic targets.
Atherosclerosis, with its complex pathogenesis, is a leading underlying cause of many cardiovascular diseases, which are increasingly prevalent in the population. Sphingolipids play an important role in the development of atherosclerosis. Key metabolites and enzymes in sphingolipid metabolism influence the pathogenesis of atherosclerosis in a variety of ways, including inflammatory responses and oxidative stress. Thus, an investigation of sphingolipid metabolism-related metabolites and key enzymes may provide novel insights and treatment targets for atherosclerosis. This review discusses various mechanisms and research progress on the relationship between various sphingolipid metabolites, related enzymes, and atherosclerosis. Finally, we look into the future research direction of phytosphingolipids.
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Zhao et al. (2025) conducted a review in Atherosclerosis. Sphingolipid metabolites and related enzymes was evaluated. Sphingolipid metabolites and related enzymes influence the pathogenesis of atherosclerosis via inflammatory responses and oxidative stress, representing potential novel treatment targets.
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