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November 16, 2008Journal of Biological ChemistryOpen Access

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

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Authors

MCMark J. CrabtreeCentre for Human GeneticsATAmy L. TathamCOPE GalwayYAYasir Al-WakeelJohn Radcliffe Hospital

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Crabtree et al. (2008) studied this question.

synapsesocial.com/papers/6a5d5c80289a75eadbc28f3ahttps://doi.org/10.1074/jbc.m805403200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stoichiometric Relationships Between Endothelial Tetrahydrobiopterin, Endothelial NO Synthase (eNOS) Activity, and eNOS Coupling in Vivo2005 · 208 citations
  2. 2Endothelial Nitric-oxide Synthase1996 · 322 citations
  3. 3Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.1995 · 177 citations
  4. 4Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols2003 · 694 citations
  5. 5The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study2002 · 267 citations