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May 14, 2019Scientific ReportsOpen Access

Simple Surface Modification of Poly(dimethylsiloxane) via Surface Segregating Smart Polymers for Biomicrofluidics

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Authors

AGAslıhan GökaltunYKYoung Bok KangMYMartin L. Yarmush

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Overview

Randomized trial shows improved hydrophilicity and reduced non-specific adsorption in microfluidics, suggesting wider applications.

Key Points

  • To enhance the hydrophilicity of PDMS while maintaining its desirable properties for microfluidic applications.
  • Developed a modification technique using PDMS-PEG copolymers during device fabrication.
  • Evaluated contact angles of modified PDMS and its hydrophilicity retention over twenty months.
  • Conducted capillary flow experiments to confirm wettability improvement.
  • PDMS-PEG-modified samples achieved contact angles as low as 23.6° ± 1°.
  • The modified PDMS showed significantly reduced non-specific adsorption of proteins like albumin and immunoglobulin G.
  • Biocompatibility was confirmed through use in a liver-on-a-chip model with no adverse effects observed.

Cite This Study

Gökaltun et al. (2019) studied this question.

synapsesocial.com/papers/6a5d75daa4cd7c4850038172https://doi.org/10.1038/s41598-019-43625-5
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