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September 9, 2020Journal of Medicinal ChemistryOpen Access

Design and Identification of a GPR40 Full Agonist (SCO-267) Possessing a 2-Carbamoylphenyl Piperidine Moiety

Hideki Furukawa Yasufumi Miyamoto Yasuhiro Hirata Koji Watanabe Yuko Hitomi Yayoi Yoshitomi Jumpei Aida Naoyoshi Noguchi Nobuyuki Takakura Kazuaki Takami Seiji Miwatashi Yoshihiko Hirozane Teruki Hamada Ryo Ito Mitsugi Ookawara Yusuke Moritoh Masanori Watanabe Tsuyoshi Maekawa

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Abstract

) effectively stimulated insulin secretion and GLP-1 release and ameliorated glucose tolerance in diabetic rats via GPR40 full agonism.

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Furukawa et al. (2020) studied this question.

synapsesocial.com/papers/6a5d81771eb962e53e89d58e https://doi.org/10.1021/acs.jmedchem.0c00843

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