Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components

We describe, herein, the synthesis, full characterization, and optical properties of four different ligands L1-L4 which associate an azo group, an imidazole unit, and a Schiff base fragment. The UV-visible absorption bands are characteristic ofπ→π⁎andn→π⁎transitions with an additional charge transfer between the azobenzene moiety and the imino group. Finally the determination of MIC 80 values against pathogenic fungi such as S. apiospermum , A. fumigatus, and C. albicans revealed that these ligands have effective antifungal properties with highest activities (MIC 80 ) on C. albicans for the azole based ligands L1-L3 . DPPH radical scavenging of the studied ligands was also tested.