Demonstrates effective control of covalent macrocycle size using metal and organic templates, suggesting new synthesis pathways.
centers, which points inward. The binding of ligands to the free coordination sites in these assemblies was found to alter the product stability, and multitopic ligands could be used to control product size. Multitopic ligands also bridged metallomacrocycles to form higher-order supramolecular assemblies, which were characterized via NMR spectroscopy, mass spectrometry, and X-ray crystallography. An efficient method was developed to reduce the imine bonds to secondary amines, leading to fully organic covalent macrocycles and cages that were inaccessible through other means.
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Lavendomme et al. (2019) studied this question.
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