August 30, 2012European Respiratory Journal
The transpulmonary pressure gradient for the diagnosis of pulmonary vascular disease
Key result
The diastolic P(pa)/P(pcw) gradient (DPG) is superior to the transpulmonary pressure gradient (TPG) for the diagnosis of "out of proportion" pulmonary hypertension.
Why the study?
Is the diastolic P(pa)/P(pcw) gradient (DPG) superior to the transpulmonary pressure gradient (TPG) for diagnosing pulmonary vascular disease in left-heart conditions?
Structured PICO
Is the diastolic P(pa)/P(pcw) gradient (DPG) superior to the transpulmonary pressure gradient (TPG) for diagnosing pulmonary vascular disease in left-heart conditions?
P
Population
Patients with left-heart conditions associated with increased pulmonary venous pressure being evaluated for intrinsic pulmonary vascular disease
E
Exposure
Diastolic P(pa)/P(pcw) gradient (DPG)
C
Comparator
Transpulmonary pressure gradient (TPG)
O
Outcome
Diagnosis of 'out of proportion' pulmonary hypertensionsurrogate
The diastolic pulmonary gradient (DPG) is a more reliable hemodynamic marker than the transpulmonary pressure gradient (TPG) for diagnosing intrinsic pulmonary vascular disease in patients with left heart disease.
Authors
Discussion
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Implication
Questions TPG >12 mmHg validity for out-of-proportion PH; leaves open optimal hemodynamic definition of pulmonary vascular disease.
Cite This Study
Naeije et al. (2012) conducted a review in Pulmonary vascular disease in left-heart conditions. Diastolic P(pa)/P(pcw) gradient (DPG) vs. Transpulmonary pressure gradient (TPG) was evaluated on Diagnosis of "out of proportion" pulmonary hypertension. The diastolic P(pa)/P(pcw) gradient (DPG) is superior to the transpulmonary pressure gradient (TPG) for the diagnosis of "out of proportion" pulmonary hypertension.