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Conjugated enynes are versatile synthetic intermediates. However, the synthesis of chiral conjugated enynes is still challenging. A highly regio- and enantioselective synthesis of conjugated enynyl amines from racemic enynyl phosphates and various amines has been developed. Up to 20:1 branch/linear ratio and 99% ee could be obtained in the presence of Rh complexes. The chiral bisoxazolinephosphine (NPN*) ligands play the key role in controlling the chemo- and stereochemistry in this transformation.
Li et al. (Tue,) studied this question.
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