Demonstrates efficient synthesis of glycoarchitectures in nanostructures, highlighting new synthetic routes.
Well-defined heteromultivalent glycoarchitectures remain challenging synthetic targets. Herein we report a [60]fullerene hexakis-adduct platform designed to undergo three orthogonally addressable click reactions, allowing the controlled conjugation of three distinct carbohydrates within a single nanostructure. The approach combines thiol-maleimide coupling with two sequential CuAAC transformations using protected and unprotected alkyne handles and supports both stepwise functionalization and one-pot reaction sequences. NMR and DOSY experiments confirmed the integrity and homogeneity of the resulting triple-functionalized glycofullerenes.
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Nieto‐Ortiz et al. (2026) studied this question.
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