What question did this study set out to answer?

This review aims to elucidate how tumor-associated fibrosis influences cellular immunity and the implications for cancer treatment.

Tumor-associated fibrosis plays a role in cellular immunity across human diseases

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Review summarizes how tumor-associated fibrosis affects cellular immunity in cancers, suggesting new immunotherapeutic strategies.

This review aims to elucidate how tumor-associated fibrosis influences cellular immunity and the implications for cancer treatment.
Summarizes fibrotic tumor stroma characteristics and types of tumor-associated fibroblasts (CAFs).
Discusses extracellular matrix components and their role in immune exclusion and dysfunction.
Reviews experimental models linking stromal states with immune phenotypes across various cancers.
Targeted ECM remodeling and CAF reprogramming can enhance immune infiltration and improve antitumor immunity.
Signaling pathways involved in fibrogenesis contribute to therapeutic resistance in tumors.
Emerging evidence highlights the complex interactions between tumor cells, CAFs, and immune cells in shaping immune responses.

Tian et al. (2026) studied this question.

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