Case report highlights the rarity of concurrent gastric adenocarcinoma and MALT lymphoma, suggesting complex management implications.
The concurrent presentation of two distinct primary malignancies in the stomach, specifically gastric adenocarcinoma (GAC) and mucosa-associated lymphoid tissue (MALT) lymphoma, is an extremely rare clinical entity. These dual primary tumors challenge standard management protocols due to their differing biologies. We present a case of a patient diagnosed with concurrent GAC and MALT lymphoma who also found to have a pulmonary nodule, creating a complex staging dilemma. Surgical pathology revealed distinct neoplastic entities: GEJ adenocarcinoma, gastric MALT lymphoma, and a pulmonary hamartoma. We provide a narrative review of selected cases from the literature to contextualize this finding. Our observations suggest that in such complex presentations, the prognosis is often driven by the higher-grade malignancy, necessitating a multidisciplinary approach to distinguish between metastatic disease and synchronous benign or indolent lesions.
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Elkourashy et al. (2026) studied this question.
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