Key result
Sodium hydrosulfide preincubation reveals correlations between platelet aggregation and biomarker concentrations in CHD.
Why the study?
There is no consensus on the role of hydrogen sulfide in regulating platelet functions and the development of thrombosis.
What is the relationship between cardiovascular biomarkers and platelet aggregation under the influence of hydrogen sulfide in patients with coronary heart disease?
Observational (n=22)
What is the relationship between cardiovascular biomarkers and platelet aggregation under the influence of hydrogen sulfide in patients with coronary heart disease?
In patients with coronary heart disease, biomarkers of hypoxic damage, endothelial dysfunction, and platelet activation correlate with platelet aggregation indices under the influence of hydrogen sulfide.
Small CHD cohort links biomarkers to H2S-modulated platelet aggregation; leaves open clinical relevance pending larger studies.
Currently, there is no consensus on the role of hydrogen sulfide (H2S) in the regulation of platelet functions and the development of thrombosis. Objective: to evaluate the relationship of biomarkers with indicators of platelet aggregation against the background of hydrogen sulfide action in patients with coronary heart disease.Materials and methods. The study included 22 patients with coronary heart disease. Patients were divided into two groups. Biomarkers were determined by multiplex analysis. Platelet aggregation activity was studied turbodimetrically. Results and discussion. In group 1, only the concentration of FABP4 was increased compared to group 2. Concentrations of BNP, CK-MB, LIGHT, interferon (IFN)α2, chemokine (CCL3)-MIP-1α, platelet growth factors PDGF-AA and PDGF-AB/BB were significantly higher in group 2 patients. Multiple correlations were found between platelet aggregation indices against the background of preincubation with sodium hydrosulfide with concentrations of biomarkers in both groups. Conclusion: It was revealed that patients with CHD group 2 had higher concentrations of biomarkers of hypoxic damage and myocardial dysfunction, endothelial dysfunction, plaque instability and platelet activation. In group 1 of patients with coronary heart disease, the concentration of FABP4 is increased.
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Трубачева et al. (2025) conducted an observational in Coronary heart disease (n=22). Sodium hydrosulfide preincubation was evaluated on Relationship of biomarkers with indicators of platelet aggregation. In patients with coronary heart disease, multiple correlations were found between platelet aggregation indices after preincubation with sodium hydrosulfide and biomarker concentrations.
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