From synthetic vesicles to living cells: Anchoring conducting polymers to cell membrane

Coupling biology with electronics is emerging as a transformative approach in developing advanced medical treatments, with examples ranging from implants for treating neurological disorders to biosensors for real-time monitoring of physiological parameters. The electrodes used for these purposes often face challenges such as signal degradation due to biofouling and limited biocompatibility, which can lead to inaccurate readings and tissue damage over time. Conducting organic polymers are a promising alternative because of their mechanical, chemical, and physical properties, which better match the ones of biological systems. They also can be synthesized in vivo to form bio-templated structures through biologically compatible manufacturing processes. Here, we report a method to achieve conductive polymer structures anchored to cell membranes, creating an intimate interface between the polymer electrode and single cells. We show that the polymer is nontoxic to cells and does not interfere with its activation, thereby making this process an interesting alternative to existing materials and electrode techniques.