Site‐Selective Derivatization and Remodeling of Erythromycin A by Using Simple Peptide‐Based Chiral Catalysts

Reversal: Simple peptide-based nucleophilic catalysts can perturb the inherent reactivity hierarchy of the polyol natural product erythromycin A (see picture). Such catalyst-dependent modifications that reorganize natural product architecture may be of utility for generation of natural product analogs.