Key result
Preclinical animal models are essential for projecting the safety and efficacy of endovascular devices and understanding the pathophysiology of restenosis following drug-eluting stent placement.
Preclinical animal models remain essential for evaluating the safety, efficacy, and pathophysiological mechanisms of novel drug-eluting stent systems and other endovascular devices.
Affirms preclinical models for endovascular device evaluation; leaves open optimal species selection and human translation.
Coronary arterial disease (CAD) is the leading cause of death in the United States, the European Union, and Canada. Percutaneous coronary intervention (PCI) has revolutionized the treatment of CAD, and it is the advent of drug-eluting stent (DES) systems that has effectively allayed much of the challenge of restenosis that has plagued the success of PCI through its 30-year history. However, DES systems have not been a panacea: There yet remain the challenges associated with interventions involving bare metallic stents as well as newly arisen concerns related to the application of DES systems. To effectively address these novel and ongoing issues, animal models are relied on both to project the safety and efficacy of endovascular devices and to provide insight into the pathophysiology underlying the vascular response to injury and mechanisms of restenosis. In this review, preclinical models of restenosis are presented, and their application and limitation in the evaluation of device-based interventional technologies for the treatment of CAD are discussed.
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Laura Perkins (2010) conducted a review in Coronary arterial disease (CAD) and restenosis. Preclinical animal models was evaluated. Preclinical animal models are essential for projecting the safety and efficacy of endovascular devices and understanding the pathophysiology of restenosis following drug-eluting stent placement.
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