Key result
Perioperative GLP-1 receptor agonist use was not associated with an increased risk of pulmonary aspiration in patients undergoing elective surgery (OR 1.07; 95% CI 0.85-1.34).
Why the study?
GLP-1 receptor agonists slow gastric emptying and may increase the risk of pulmonary aspiration, particularly in patients undergoing elective surgery.
Does perioperative GLP-1 receptor agonist use increase the risk of pulmonary aspiration in patients undergoing elective surgery?
Cohort (n=392,065)
Does perioperative GLP-1 receptor agonist use increase the risk of pulmonary aspiration in patients undergoing elective surgery?
Odds Ratio: 1.07 (95% CI 0.85–1.34)
Absolute Event Rate: 0.8% vs 0.7%
p-value: p=0.61
Perioperative use of GLP-1 receptor agonists is not associated with an increased risk of pulmonary aspiration in patients undergoing elective surgery.
GLP-1 agonists may be continued perioperatively without added aspiration risk; leaves open need for randomized confirmation.
Glucagon-like-peptide-1 (GLP-1) receptor agonists are approved for the treatment of type II diabetes mellitus and obesity. These agents slow gastric emptying and may increase the risk of pulmonary aspiration, particularly in patients undergoing elective surgery. We used a claims database to examine the association between perioperative GLP-1 receptor agonist use and the risk of pulmonary aspiration. A total of 392 065 patients including 15 745 (4.0%) who used GLP-1 receptor agonist who underwent elective surgery were identified. The rate of pulmonary aspiration was 0.8% in those who received GLP-1 receptor agonists versus 0.7% in those who had not ( P = 0.61). After adjusting for other risk factors for aspiration, there was no association between GLP-1 agonist use and aspiration (OR = 1.07; 95% CI, 0.85-1.34).
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Wright et al. (2025) conducted a cohort in Elective surgery (n=392,065). GLP-1 receptor agonist vs. No GLP-1 receptor agonist use was evaluated on Pulmonary aspiration (OR 1.07, 95% CI 0.85-1.34, p=0.61). Perioperative GLP-1 receptor agonist use was not associated with an increased risk of pulmonary aspiration in patients undergoing elective surgery (OR 1.07; 95% CI 0.85-1.34).
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